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Clare Lloyd

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Clare Lloyd
FRSB
Born
Clare Margaret Lloyd
Alma materKing's College London (PhD)
Scientific career
FieldsInflammation[1]
InstitutionsImperial College London
Harvard University
Millennium Pharmaceuticals
ThesisMechanisms of nephritis during murine malarial infections (1991)
Websiteimperial.ac.uk/people/c.lloyd

Clare Margaret Lloyd FRSB FMedSci is a Professor of Medicine and Vice Dean for Institutional Affairs at Imperial College London. She investigates allergic immunity in early life.[1]

Early life and education

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Lloyd earned her BSc and PhD in immunology at King's College London.[2] She earned her Bachelor's degree in 1987 and her PhD in 1991.[3] She was awarded a National Kidney Research Fund Fellowship and joined the United Medical and Dental Schools of Guy's and St Thomas' Hospitals.[2] Her work considered mouse models of glomerulonephritis. She joined Harvard University to work on chronic inflammatory glomerulonephritis.[2] She became interested in the mechanisms of cell recruitment. She was involved with early studies that looking at the cloning, expression and function of chemokine.[4] Her group demonstrated that T helper cells were the initial responders to CCR3 and CCR4 pathways, but the increase in CCR4 positive cells results in the long-term representation of T helper cells in vivo.[5] LLoyd studied the role of these chemokines in allergic lung inflammation.[6] She looked to better characterise the spatial patterns of chemokine expression to inform therapeutic strategies that limit the side-effects of allergen exposure.[6]

Career and research

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After her postdoctoral fellowship at Harvard University, Lloyd joined at Millennium Pharmaceuticals in 1996 to work on models to characterise novel genes.[2] She returned to the UK in 1999, joining Imperial College London as a Wellcome Trust Senior Fellow.[2] She continued her interest in allergens, looking at the roles for cells and molecules involved in pulmonary inflammation.[2] She is part of the Asthma UK Centre in Allergic Mechanisms of Asthma.[7] She is a member of the British Society for Immunology and Wellcome Trust Infection, Immunity and Immunophenotyping.[8] Lloyd studies the lung cells of children who suffer from asthma and severe wheeze.[9] She has studied why pollen and dust can trigger reactions in some people but not others.[10] She became interested in why exposure to allergens and infections in early life had such an influence on programming pathways to maintain pulmonary homeostasis.[11][12] She demonstrated that Interleukin 9 can mediate inflammation of asthma.[13]

She was appointed Professor in Respiratory Immunology in 2006.[2] She is co-lead of the respiratory division.[14] Her research group, the Lloyd Lab, look at the interactions between lung cells and infiltrating inflammatory cells.[15] Lloyd was awarded the Imperial College London Rectors Medal for her Research Supervision in 2014.[16] In 2018, she demonstrated that the ICOS/ICOS‐L pathway could be a therapeutic target in asthma.[17]

Academic service

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She was the lead National Heart and Lung Institute Athena Swan lead between 2009 and 2014, achieving the first Silver award for a medical department in the UK.[18] She pushed for the improvement of the Imperial College London mentoring scheme, in an effort to support early career researchers.[18] In 2016 she was appointed Dean of Institutional Affairs at Imperial College London.[18] She serves on the scientific advisory board of Science Magazine and is an editor of Nature Mucosal Immunology and the European Journal of Immunology.[19][20][21] She serves on the Royal Society Newton International Fellowships board.[22]

Awards and honours

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References

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  1. ^ a b Clare Lloyd publications indexed by Google Scholar Edit this at Wikidata
  2. ^ a b c d e f g "Professor Clare Lloyd". imperial.ac.uk. Imperial College London. Retrieved 2018-12-16.
  3. ^ ORCID 0000-0001-8977-6726
  4. ^ Gutierrez-Ramos, Jose-Carlos; Gearing, David; Coyle, Anthony J.; Proudfoot, Amanda E. I.; Powers, Christine A.; Dussault, Barry; Yu, Gary; Jia, Gui-Quan; Lloyd, Clare M. (1999). "Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation". The Journal of Immunology. 163 (1): 403–411. doi:10.4049/jimmunol.163.1.403. ISSN 1550-6606. PMID 10384142.
  5. ^ Lloyd, Clare M.; Delaney, Tracy; Nguyen, Trang; Tian, Jane; Martinez-A, Carlos; Coyle, Anthony J.; Gutierrez-Ramos, Jose-Carlos (2000). "Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo". The Journal of Experimental Medicine. 191 (2): 265–274. doi:10.1084/jem.191.2.265. ISSN 0022-1007. PMC 2195756. PMID 10637271.
  6. ^ a b Lloyd, Clare (2002). "Chemokines in allergic lung inflammation". Immunology. 105 (2): 144–154. doi:10.1046/j.1365-2567.2002.01344.x. ISSN 0019-2805. PMC 1782646. PMID 11872089.
  7. ^ "Prof. Clare Lloyd | Asthma UK Centre". asthma-allergy.ac.uk. Retrieved 2018-12-16.
  8. ^ "Home | 3i Consortium - Wellcome Trust Sanger Institute". immunophenotype.org. Retrieved 2018-12-16.
  9. ^ "Wheezing and Asthma: Earlier Diagnosis and Treatment | Action Medical Research | Children's Charity". action.org.uk. 2013-04-10. Archived from the original on 2018-12-17. Retrieved 2018-12-16.
  10. ^ "Lungs". Wellcome Collection. Retrieved 2018-12-16.
  11. ^ Lloyd, Clare M.; Saglani, Sejal (2010). "Asthma and allergy: The emerging epithelium". Nature Medicine. 16 (3): 273–274. doi:10.1038/nm0310-273. PMC 3380503. PMID 20208514.
  12. ^ Lloyd, Clare M.; Hawrylowicz, Catherine M. (2009). "Regulatory T Cells in Asthma". Immunity. 31 (3): 438–449. doi:10.1016/j.immuni.2009.08.007. ISSN 1074-7613. PMC 3385348. PMID 19766086.
  13. ^ Lloyd, Clare M.; Phimister, Elizabeth G.; Harker, James A. (2018). "Epigenetic Control of Interleukin-9 in Asthma" (PDF). New England Journal of Medicine. 379 (1): 87–89. doi:10.1056/NEJMcibr1803610. hdl:10044/1/61609. ISSN 0028-4793. PMID 29972761. S2CID 49651778.
  14. ^ "Structure and key people". Imperial College London. Retrieved 2018-12-16.
  15. ^ "People – LLOYD LAB". Retrieved 2018-12-16.
  16. ^ "Honours and Memberships - Professor Clare Lloyd". imperial.ac.uk. Retrieved 2018-12-16.
  17. ^ Uwadiae, Faith I.; Pyle, Chloe J.; Walker, Simone A.; Lloyd, Clare M.; Harker, James A. (2018). "Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease". Allergy. 74 (4): 650–662. doi:10.1111/all.13602. ISSN 1398-9995. PMC 6492018. PMID 30220084.
  18. ^ a b c "Professor Clare Lloyd on being Vice Dean (Institutional Affairs)". FoM Staff Blog. 2017-11-27. Retrieved 2018-12-16.
  19. ^ "Advisory Board". Science | AAAS. 2018-01-31. Retrieved 2018-12-18.
  20. ^ "About the Editors | Mucosal Immunology". www.nature.com. Retrieved 2018-12-18.
  21. ^ "European Journal of Immunology". onlinelibrary.wiley.com. doi:10.1002/(ISSN)1521-4141. hdl:2027.42/37955. S2CID 250212720. Retrieved 2018-12-18.
  22. ^ "Clare Lloyd | Royal Society". royalsociety.org. Retrieved 2018-12-18.
  23. ^ "Professor Clare Lloyd | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 7 March 2020.
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